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How to Reduce Integration Errors in
Chromatographic Analysis:
When Peaks are of Approximately Equal Size

 Conducted by Merlin K. L. Bicking, Ph.D.

September 21, 2007

Are your chromatographic results different than you expect?  Do you suspect that one problem might be caused by peak integration errors?  Are you unsure about which integration method to use?

You are not alone!  These questions have plagued chromatographers for many years, and while modern integration systems can give us many options, they don’t offer any advice on which option works best in a particular situation.  This seminar will provide some of the answers to your questions.  Based on recent integration research, this presentation will discuss how to minimize integration errors when two peaks are of approximately equal size (i.e., one peak is at least five percent of the other peak).

We will briefly discuss how integrators work, and how to set up your data collection system so that you have enough peak information to produce accurate results.  After a review of basic resolution concepts, we will outline the most popular integration options (drop, valley, and skim).  Integration errors resulting from the use of each integration option will then be presented for a variety of peak size ratios, when the smaller peak is either before or after the larger peak, at resolutions values ranging from 1.0 to 2.0.  Finally, the sources of these integration errors will be discussed from a chromatographic perspective.

This seminar will be conducted on the telephone and is presented by Dr. Merlin K. L. Bicking, worldwide expert on liquid chromatography. In this unique  seminar format, lasting just one hour, you will be able to follow along with a PowerPoint presentation and ask questions and interact with Dr. Bicking during the  seminar.  A detailed outline and Dr. Bicking’s qualifications follow below.

How to Reduce Integration Errors in Chromatographic Analysis: When Peaks are of Approximately Equal Size

Part I

• Introduction to chromatographic integrators.

Part II

• What does resolution mean when the peaks are not of equal size?

• What integration baseline options are available?

Part III

• Integration errors for each baseline option and recommendations for selecting the best option.

• Sources of integration errors.

Part IV    Questions and Answers / Discussion

• Dr. Bicking will field your questions live on the phone. You will hear all questions and answers from all participants of this teleseminar.

Instructor

Merlin K. L. Bicking, Ph.D.

Dr. Merlin K. L. Bicking is President of ACCTA, Inc., an analytical chemistry consulting and training company he founded in 1993.  He has more than 25 years experience as an analytical chemist and practicing chromatographer.  Dr. Bicking has published numerous papers on a wide variety of analytical topics, including liquid chromatography retention mechanisms, LC, GC, and SFE method development and optimization, and sample preparation. 

Dr. Bicking provides consulting services across many industries on a diverse range of topics, including analytical method development and optimization, formulation development and optimization, product characterization, and failure analysis.  He also trains analytical laboratory staff, and his Practichem Series of Training Seminars® is presented regularly for private corporations and at professional meetings.  Dr. Bicking has held positions with the State University of New York - Buffalo, Battelle Memorial Institute, Twin City Testing Corporation, and Uroplasty, Inc.  He holds a B.S. in Chemistry from the University of Wisconsin - River Falls and a Ph.D. in Organic-Analytical Chemistry from Iowa State University.

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All registrations include handout materials. Once you’re registered, you will receive via e-mail (the e-mail address you provide in your registration) the dial-in instructions and the web location to download the handout materials.

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Get the CD and handout GMP070921E - CD and Handout materials How to Reduce Integration Errors in Chromatographic Analysis: When Peaks are of Approximately Equal Size CD price includes HANDOUT MATERIALS and audio CD. CD will be shipped three weeks after the seminar

$397.00