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How to Reduce Integration Errors in
Chromatographic Analysis:
When Peaks are Not the Same Size

 Conducted by Merlin K. L. Bicking, Ph.D.

September 28, 2007
 

When you are analyzing a small peak next to a large one, are your chromatographic results different than you expect?  Do you suspect that one problem might be caused by peak integration errors?  Are you unsure about which integration method to use?

You are not alone!  These questions have plagued chromatographers for many years, and while modern integration systems can give us many options, they don’t offer any advice on which option works best in a particular situation.  This seminar will provide some of the answers to your questions.  Based on recent integration research, this presentation will discuss how to minimize integration errors when the two peaks are not the same size (i.e., the small peak is less than about five percent of the large peak).

We will briefly review the recommendations for integrating peaks that are approximately the same size.  After a review of basic resolution concepts, we will review the three main baseline integration options – drop, valley, and skim.  Integration errors resulting from the use of each integration option will then be presented for a variety of peak size ratios, including situations when the small peak is less than 0.5 % of the large peak, and when the smaller peak is either before or after the larger peak, at resolutions values ranging from 1.0 to 2.0. 

Finally, a number of real world integration issues will be presented and discussed.

This seminar will be conducted on the telephone and is presented by Dr. Merlin K. L. Bicking, worldwide expert on liquid chromatography. In this unique  seminar format, lasting just one hour, you will be able to follow along with a PowerPoint presentation and ask questions and interact with Dr. Bicking during the  seminar.  A detailed outline and Dr. Bicking’s qualifications follow below.

How to Reduce Integration Errors in Chromatographic Analysis: When Peaks are Not the Same Size

Part I

• Review of integration issues when peaks are of approximately equal size.

Part II

• Review of resolution issues and integration baseline options.

Part III

• Integration errors for each baseline option and recommendations for selecting the best option.

Part IV

• Dealing with more complex issues – noise, tailing, unresolved components, and other baseline problems.

Part V    Questions and Answers / Discussion

• Dr. Bicking will field your questions live on the phone. You will hear all questions and answers from all participants of this teleseminar.

Instructor

Merlin K. L. Bicking, Ph.D.

Dr. Merlin K. L. Bicking is President of ACCTA, Inc., an analytical chemistry consulting and training company he founded in 1993.  He has more than 25 years experience as an analytical chemist and practicing chromatographer.  Dr. Bicking has published numerous papers on a wide variety of analytical topics, including liquid chromatography retention mechanisms, LC, GC, and SFE method development and optimization, and sample preparation. 

Dr. Bicking provides consulting services across many industries on a diverse range of topics, including analytical method development and optimization, formulation development and optimization, product characterization, and failure analysis.  He also trains analytical laboratory staff, and his Practichem Series of Training Seminars® is presented regularly for private corporations and at professional meetings.  Dr. Bicking has held positions with the State University of New York - Buffalo, Battelle Memorial Institute, Twin City Testing Corporation, and Uroplasty, Inc.  He holds a B.S. in Chemistry from the University of Wisconsin - River Falls and a Ph.D. in Organic-Analytical Chemistry from Iowa State University.

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All registrations include handout materials. Once you’re registered, you will receive via e-mail (the e-mail address you provide in your registration) the dial-in instructions and the web location to download the handout materials.

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Get the CD and handout GMP070928E - CD and Handout materials How to Reduce Integration Errors in Chromatographic Analysis: When Peaks are NOT the Same Size CD price includes HANDOUT MATERIALS and audio CD. CD will be shipped three weeks after the seminar

$397.00